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Autoimmune Disease Predispositions and Pregnancy

A short overview of the role of genetic predispositions to autoimmune disease in a reproductive immunology assessment.

April 1, 2022 Pregmune Team
Autoimmune disease predisposition

Many autoimmune diseases can raise a patient’s chances for adverse pregnancy outcomes, which is why expectant mothers with antiphospholipid syndrome, lupus, rheumatoid arthritis, and other autoimmune disorders are considered high-risk pregnancies. However, many people remain undiagnosed for autoimmune conditions.

Autoimmune diseases are thought to arise from a combination of a person’s genetics and environment. Although being genetically predisposed to autoimmunity might raise a person’s chances for developing an autoimmune disease, it is not a guarantee.


Human Leukocyte Antigen (HLA) genes play an integral role in activating the immune response. Some HLA alleles change the features of a person’s HLAs to make them more likely to inappropriately trigger the immune response and develop an autoimmune condition. An autoimmune disease predisposition test looks at different alleles of the patient’s HLA genes which might predispose the patient to autoimmune issues than can interfere with a healthy pregnancy.

Our analysis indicates HLA alleles and haplotypes that have been shown to predispose to certain autoimmune conditions. The presence of one or more predisposing HLA alleles/haplotypes is not diagnostic of the existence of an autoimmune condition. However, when combined with other analysis in the IRMA report, the presence of specific alleles/haplotypes can provide valuable insight into the state of the patient’s immune system that could be contributing to failure to initiate or maintain pregnancy. HLA alleles and haplotypes that contribute to autoimmunity may also directly lead to an inability to appropriately establish maternal immune tolerance to an embryo or fetus.

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About Pregmune: We’re an innovative reproductive health technology company, built on a solid foundation of data gained from decades of experience and thousands of successful pregnancies. Our team of fertility specialists and scientists are using artificial intelligence to decipher the complexity of the immune system and help patients grow the families of their dreams.

Our first product, IRMA, provides patients and their doctors with a personalized report and evidence-based treatment plan that addresses immunological sources of unexplained infertility, recurrent pregnancy loss, and recurrent implantation failure.