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Rheumatoid Arthritis and Pregnancy: Research Review

A short overview of the impact of rheumatoid arthritis antibodies on pregnancy - and the science behind it.

April 1, 2022 Pregmune Team
Rheumatoid arthritis

Cyclic citrullinated protein (CCP) antibodies and rheumatoid factor are antibodies that can indicate rheumatoid arthritis and some other autoimmune diseases. These antibody tests are included in the IRMA report as one of the immunological factors that can impact pregnancy.

Many autoimmune diseases can raise a patient’s chances for adverse pregnancy outcomes, which is why expectant mothers with antiphospholipid syndrome, lupus, rheumatoid arthritis, and other autoimmune disorders are considered high-risk pregnancies. However, many people remain undiagnosed for autoimmune conditions.


Anti-citrullinated protein antibodies (anti-CCP) and rheumatoid factor (RF) are two tests used to detect rheumatoid Arthritis (RA). Elevated RF levels are found in collagen vascular diseases such as SLE, RA, scleroderma, Sjogren’s Syndrome or thyroid disease.

RF is not very specific for RA diagnosis and can also be detected in patients with other rheumatic disorders, infections, as well as in apparently healthy patients1. Anti-CCP antibodies are more specific than RF for RA2.

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About Pregmune: We’re an innovative reproductive health technology company, built on a solid foundation of data gained from decades of experience and thousands of successful pregnancies. Our team of fertility specialists and scientists are using artificial intelligence to decipher the complexity of the immune system and help patients grow the families of their dreams.

Our first product, IRMA, provides patients and their doctors with a personalized report and evidence-based treatment plan that addresses immunological sources of unexplained infertility, recurrent pregnancy loss, and recurrent implantation failure.


1. Eggeland T, Munthe E (1983) The role of the laboratory in rheumatology. Rheumatoid factors Clin Rheum Dis 9:135–160.
2.Dos Anjos LM, Pereira IA, Orsi E, Seaman AP, Burlingame RW, Morato EF (2009) A comparative study of IgG second- and thirdgeneration anti-cyclic citrullinated peptide (CCP) ELISAs and their combination with IgA third-generation CCP ELISA for the diagnosis of rheumatoid arthritis. Clin Rheumatol 28:153–158.