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How It Works

IRMA from Pregmune is the first-ever comprehensive, AI-powered fertility assessment that identifies often-overlooked causes for reproductive failure — and provides expert guidance for personalized follow-up treatment with your own doctor.

Follow these easy steps to get started today:

  1. 1Register for your account

    Register for a free account on our patient portal and request your IRMA assessment by completing all patient forms and the New Patient Questionnaire online. Both female patient and male partner (if applicable) require separate patient portal accounts.

    Please note: IRMA is available to U.S. patients only. International patients will need a physician in the U.S. to complete consult request form and order lab work. Lab work will need to be performed in the U.S.
    If you are not an U.S. patient, please see our IRMA Basic report.

  2. 2Return your completed Referral Form

    Download the Referral Form for your primary physician or fertility specialist to complete. Then return the completed form by email to [email protected], fax it to +1 (201) 928-5900 or upload it to our patient portal.

  3. 3Pay online for your IRMA assessment

    Once we’ve reviewed and approved your completed Referral Form, we’ll send a confirmation email including your bill to be paid online through your account on our patient portal. Lab work is billed separately to you or to your insurance carrier from the independent laboratories to which Pregmune will order the required tests. Reimbursement eligibility and amount covered is dependent on your insurance carrier and plan. Pregmune will provide the patient with lab work requisitions listing all tests required to prepare the IRMA assessment. These requisitions have to be be signed off by your own physician, alternatively Pregmune may sign them off with the authorization of your physician.

  4. 4Visit two local labs for lab work

    We will order lab work for female patient and male partner (if applicable) and send you the instructions to set up your appointments for blood work at two convenient lab locations (LabCorp and ReproSource). Lab work is billed separately to you or to your insurance carrier from the independent laboratories to which Pregmune will order the required tests. Reimbursement eligibility and amount covered is dependent on your insurance carrier and plan.

  5. 5Get your personalized IRMA report within 6 weeks

    Once we receive the lab results which may take up to 5 weeks, we will process your report. You will receive an email when your report is available on our patient portal, and we will send it to your physician so together you can discuss the findings and plan for future treatments.


What is the IRMA assessment?

IRMA is a reproductive immunology assessment that will help identify the potential causes of your infertility, will estimate your chances for successful live birth based on our customized artificial intelligence algorithm, and will provide you with expert guidance for follow-up treatment for improved chance of success.

How much does IRMA cost?

Patients are responsible for 2 different types of costs:

1) Cost of the IRMA assessment: IRMA costs $1,850 USD (pricing as of 12/01/2023) and must be fully paid by the patient to Pregmune, as out of pocket. It does not include the cost of the blood analysis performed by independent laboratories.

2) Costs of lab work: Lab work will be billed to the patient or insurance company directly from the laboratory itself. Eligibility and costs of lab work largely depends on the patient’s insurance provider and plan. Please contact Labcorp at +1 (800) 845-6167, ReproSource at +1 (800) 667-8893 and your insurance carrier to ask for support in this regard.

Will I be covered by my insurance?

Pregmune providers are out-of-network with all insurance companies. The patient can attempt to submit a claim for reimbursement for the cost of IRMA to their insurance carrier by presenting the statement from Pregmune, which will include all the information and service codes that are required by most insurance carriers in order to evaluate reimbursement eligibility and amount.

Do I need my own physician?

Yes. All patients MUST have their own health care provider (i.e. Primary Care Physician, Reproductive Endocrinologist, OB/GYN) to request a consult to Pregmune by completing and signing the Referral Form. Pregmune will also provide the patient with lab work requisitions listing all tests required to prepare the IRMA report. Pregmune will automatically receive a copy of lab results from the labs, and then your IRMA report will be prepared. The physician that signs the Referral Form and orders the lab work will receive a copy of the IRMA report and will decide how to implement recommendations in the Pregmune report for the patient.

Can I discuss my results with a Pregmune fertility specialist?

No. Your IRMA assessment includes a comprehensive report that will assist your physician in diagnosing and treating your reproductive issues. It is advised to consult with your healthcare provider (gynecologist, reproductive endocrinologist or reproductive immunologist) to review the report.

Can Pregmune help with a fertility treatment plan?

Your IRMA report will provide you and your health care provider with expert guidance for follow-up treatment for improved chances of success. It is advised to discuss the recommendations with your healthcare provider.

Where are the laboratory samples processed?

Laboratory samples are collected and processed at external, independent laboratories (LabCorp and ReproSource) appointments at the most convenient location. Lab work are ordered by the patient’s own physician (see "Do I need my own physician" for details) based on Pregmune’s directives. The patient will receive instructions on how to book appointments at the most convenient lab locations.

When will my results be ready?

On average, a patient should expect to receive their IRMA report within 6 weeks from the time all lab samples have been received at the laboratory.

Can medications affect my results?

Yes, some medications may have an impact on your immune system or hormone levels.

If you are on a short-term medication, we recommend finishing your treatment before collecting your blood sample.

If you are on regular medications, let us know in your questionnaire. Please note that you will have to get your blood draw before taking your dose.

Some surgical procedures, such as exploratory laparoscopy or D&C (dilatation and curettage) may also have an impact on your immune system. It is advised to wait 4 weeks, from the time of the procedure, to have your IRMA testing drawn.

Can I have testing done for an IRMA report while I am pregnant?

No. The IRMA report is designed to assess the causes of your infertility at baseline (while not pregnant). If you are currently pregnant and need pregnancy monitoring, please consult our AIMY report page.

Will a physician review my results?

Yes. Every single lab test result is reviewed, validated and interpreted by a member of the Pregmune medical and research team.

How will I receive the completed report?

The IRMA report will be made available on the Pregmune Patient Portal as a PDF file that the patient can download, read and discuss with their referring physician.

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