Reproductive Immunology Assessment

Finally, clarity for your fertility journey

IRMA is the first comprehensive assessment designed to uncover hidden immune-related factors often overlooked by traditional fertility testing. It was designed for women seeking answers for unexplained infertility, recurrent miscarriage, failed IVF, or implantation failure.

Whether you have experienced repeated setbacks, have limited eggs or embryos, or simply desire greater clarity, IRMA provides actionable insights before the next step in your fertility journey.

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Physician-designed

Data-driven

Results within 5 weeks

Pregmune — answers for your fertility journey

What We Assess

Critical insights beyond routine fertility testing

IRMA evaluates six key immune and reproductive health factors often overlooked in standard fertility workups to help you build the most informed path toward having a baby.

Parental Compatibility
(HLA mismatches)

Natural Killer Cell
Cytotoxic Activity

Systemic
Inflammation

Thrombophilia

Regulatory T Cell
Deficiency

Autoimmune
Antibodies

Sample IRMA Assessment Preview

AI-Powered

NK Cell Activity Th1/Th2 Ratio Antiphospholipid Ab KIR-HLA-C Thyroid Panel ANA

Immune-Related Live Birth Probability Moderate Risk

LowerModerateHigher

3 immune findings identified that may contribute to implantation failure or pregnancy complications: elevated NK cell cytotoxic activity, a skewed Th1 immune profile, and a KIR AA haplotype pattern associated with increased reproductive immune risk. Based on the overall immune profile, the AI assessment estimates an above-average likelihood of successful live birth with personalized immune-guided care.

Self-Assessment

Is IRMA Right for You?

Answer three quick questions to find out whether IRMA may be a valuable next step in your fertility journey.

Quick Self-Assessment

Question 1 of 3

Where are you in your fertility journey?

Question 2 of 3

Have you experienced any of the following?

Question 3 of 3

Do you have a history of any of the following conditions?

Likelihood immune factors are involved

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Get Started

What to Expect

From referral to answers…

A clear, step-by-step process that provides you and your physician with the insights needed to develop a treatment plan tailored to your unique fertility journey.

Register & Insurance Check

Register for My Portal, upload your insurance information, and we'll verify your insurance coverage for laboratory testing.

Lab Draw

We coordinate bloodwork through LabCorp and ReproSource — at a location convenient to you.

Results Analysis

55+ immune biomarkers are analyzed by our proprietary IRMA algorithm and reviewed by our team.

Your Report

Receive a comprehensive, actionable immune report — shared with you and your physician within 5 weeks.

Patient Stories

Real women. Real answers.

For many of our patients, IRMA was the first test that actually explained what had been happening.

After three failed IVF cycles and no explanation from anyone, IRMA finally identified elevated NK cell activity. We treated it, transferred again — and I'm now 22 weeks pregnant.

Sarah M.

3 failed IVFs before IRMA

Now 22 weeks pregnant

I had been told everything looked "normal." IRMA found antiphospholipid antibodies — something no one had ever tested for. My doctor started treatment and I finally carried to term.

Alyssa T.

4 miscarriages, "unexplained"

Healthy baby, born 2024

My REI referred me to Pregmune after two failed donor egg transfers. IRMA identified a KIR-HLA mismatch. My doctor adjusted protocol and we finally had success with the next transfer.

Michelle K.

2 failed donor egg cycles

Successful transfer, 2025

Common Questions

Frequently Asked Questions

IRMA is a comprehensive reproductive immune assessment that evaluates 55+ biomarkers involved in implantation and early pregnancy. While traditional fertility testing focuses on hormones, anatomy, and embryo quality, immune-related factors are often overlooked. IRMA helps uncover hidden immune patterns that may impact fertility and pregnancy outcomes.

No referral is required to get started. You can begin the process directly at www.pregmune.com. A physician referral will, however, be required before your laboratory orders can be placed. IRMA results are most valuable when reviewed alongside your fertility specialist, and Pregmune can also work directly with your physician if you prefer a coordinated approach to care.

Pregmune is transparent about all costs — there are no surprise fees. Pregmune reports are currently self-pay. You may be able to use an FSA/HSA account, but we recommend checking with your benefits provider. Lab testing may be partially or fully covered by your insurance and Pregmune will assist with verifying your benefits in advance of purchasing your report.

From the time your lab draw is completed, IRMA results are typically ready within 5 weeks. The report is reviewed by the Pregmune team before delivery to ensure accuracy.

Yes. Pregmune supports both direct patient registration and physician referrals. If your doctor would like to learn more about integrating IRMA into their practice, direct them to our For Physicians page or contact us directly.

Immunosuppressants, certain hormonal treatments, and recent surgeries (laparoscopy, D&C) may affect immune readings. If you're on short-term medications, we generally recommend completing the course before your blood draw. For ongoing medications, note them in your intake questionnaire and the team will advise on timing.

IRMA is currently available to US-based patients, as lab work is processed through US-certified laboratories (LabCorp and ReproSource). We are working to expand internationally — contact us to be notified when access opens in your region.

Medical Disclaimer

Patients and physicians should always consult with a licensed medical professional before making any clinical decisions, including starting or discontinuing any treatment. Any information provided by Pregmune, including but not limited to the IRMA Report, AIMY Report, test results, risk estimates, supporting documentation, email communications or other related content (collectively, "Pregmune Content"), is intended for informational purposes only. This content is not medical advice and should not be used as a substitute for professional medical evaluation, diagnosis, or treatment. Pregmune Content is not a recommendation for any specific treatment plan, therapy, medication, or course of action. It is designed to support, not replace, the relationship between patients and their qualified healthcare providers. Pregmune does not provide medical care, and its reports and communications should never delay or override clinical judgment.